Gozani Group Publications by Year
Note: *Authors Contributed Equally; # Co-correspondence; lab started in 20052024
Park J*, Wu J*, Szkop KJ, Jeong J, Jovanovic P, Husmann D, Flores NM, Francis JW, Chen YC, Benitez AM, Zahn E, Song S, Ajani JA, Wang L, Singh K, Larsson O, Garcia BA, Topisirovic I, Gozani O# and Mazur PK#. SMYD5 methylation of rpL40 links ribosomal output to gastric cancer malignant progression. 2024 Nature, Aug;632(8025):656-663. PMID: 39048817
Francis JW*, Hausmann S*, Ikram S*, Yin K*, Mealey-Farr R., Flores NM, Trinh AT, Chasan T, Thompson J, Mazur PK#, and Gozani O#. FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis. 2024 Molecular Cell, Mar 12:S1097-2765(24). PMID: 38508183
Casanova AG, Roth GS, Hausmann S, Lu X, Bischoff LJM, Froeliger EM, Belmudes L, Bourova-Flin E, Flore NM, Benitez AM, Chasan T, Caporicci M, Vayr J, Blanchet S, Ielasi F, Rousseaux S, Hainaut P, Gozani O, Le Romancer M, Coute Y, Palencia A, Mazur PK, Reynoird N. (2024). Cytoskeleton remodeling induced by SMYD2 methyltransferase drives breast cancer metastasis. Cell Discovery. 2024 Jan 31;10(1):12. PMID: 38296970
2023
Gray ZH, Chakraborty D, Duttweiler RR, Alekbaeva GD, Murphy SE, Chetal K, Ji F, Ferman BI, Honer MA, Wang Z, Myers C, Sun R, Kanishkan HU, Toma MM, Bondarenko EA, Santoro JN, Miranda C, Dillingham ME, Tang R, Gozani O, Jin J, Skorski T, Duy C, Lee H, Sadreyev RI, Whetstine JR. (2023). Epigenetic balance ensures mechanistic control of MLL amplification and rearrangement. Cell 2023 Oct 12;186(21):4528-4545. PMID: 37788669
Mack R and O. Gozani (2023). Functional epigenomics: chromatin complexity untangled. Nature Struct Mol Biol. 2023 Oct;30(10):1403-1405. PMID: 37684554
Chen C, Shin JH, Fang Z, Brennan K, Horowitz NB, Pfaff KL, Welsh EL, Rodig SJ, Begaert O, Gozani O, Uppaluri R and JB Sunwoo. Targeting KDM2A enhances T cell infiltration in NSD1-deficient head and neck squamous cell carcinoma. Cancer Research, 2023, Jun 13:CAN-22-3114; PMID: 37311054
Francis JW, Shao Z, Narkhede P, Trinh AT, Lu J, Song J and O. Gozani. The FAM86 domain of FAM86A confers substrate specificity to promote EEF2-Lys525 methylation. J Biological Chemistry, 2023, May 18:104842; PMID: 37209825
Mealey-Farr R, Jeong J*, Park J*, Liu S, Hausmann S, Francis JW, Angulo Ibanez M, Cho J, Chua K, Mazur PK and O. Gozani. Antibody toolkit to investigate eEF1A methylation dynamics in mRNA translation elongation. J Biological Chemistry, 2023, Apr 23:299(6):104747; PMID: 37094697
2022
Janas JA, Zhang L, Luu, JH, Demeter J, Meng L, Marro SG, Mail M, Mooney NA, Schaukowitch K, Ng, YH, Yang N, Huang Y, Neumayer G, Gozani O, Elias JE, Jackson PK and M. Wernig. Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation. Molecular Cell, 2022, Nov 17; PMID: 36417913
Peters CE, Schulze-Gahem U, Echkardt M, Jang GM, Xu J, Pulido EH, Bardine C, Craik CS, Ott M, Gozani O, Verba KA, Huttenhain R, Carette JE and NJ Krogan. Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3. Nature Communications, 2022, Sep 8;13(1):5282; PMID: 36075902
2021
Sengupta D*, Zeng L*, Li Y*, Hausmann S, Ghosh D, Yuan G., Nguyen TN, Lyu R, Caporicci M, Morale Benitez A, Coles GL, Kharchenko V, Czaban I, Azibhek D, Fischle W, Jaremko M, Wistuba II, Sagę J, Jaremko L, Li W, Mazur PK# and O. Gozani#. NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis. Molecular Cell, 2021, Nov 4;81(21):4481-4492. PMID: 34555356
John P Coan, Shuo Liu and Or Gozani. Chemical linguistics: Reading the modified proteome. Molecular Cell, 2021, Jun 17;81(12):2501-2503. PMID: 34143967
Cheung P, Schaffert S, Chang SE, Dvorak M, Donato M, Macaubas C, Foecke MH, Li TM, Zhang L, Coan JP, Schubert GS, Grom AA, Henderson LA, Nigrovic PA, Elias JE, Gozani O, Mellins ED, Kharti P, Utz, PJ and Alex J Kuo. Repression of CTSG, ELANE and PRTN3-mediated histone H3 proteolytic cleavage promotes monocyte-to-macrophage differentiation. Nature Immunology, 2021, Jun;22(6):711-722. PMID: 34017121
Zanoni P*, Steindl K*, Sengupta D*, Jose P, Bahr A, Sticht H, Lang-Muritano M, van Ravenswaaij-Arts CMA, Shinawi M, Andrews M, Attie-Bitach T, Maystadt I, Belnap N, Benoit V, Delplancq G, de Vries BBA, Grotto S, Lacombe D, Larson A, Mormons J, Ounap K, Petrilli G, Pundit R, Ramsey K, Blok LS, Tsatsaris V, Vitobello A, Fairer L, Wheeler PG, Weeverrs MR, Wojcik M, Zweieer M, Gozani O#, Rauch A#. Loss-of-function and missense variants in NSD2 cause decreased methylation activity and are associated with a distinct developmental phenotype. Genetic Medicine, 2021, May 3. PMID: 33941880
Ren M, Fan H, Grimm SA, Kim JJ, Li L, Gut Y, Pedell CJ, Tan XF, Zhang ZM, Coan JP, Yin J, Kim DI, Gao L, Cai L, Khudaveerdyan N, Cetin B, Patel DJ, Wang Y, Cui Q, Strahl BD, Gozani O, Miller KM, O’Leary SE, Wade PA, Wang GG, Song, J. DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation. Nature Communications, 2021, May 3;12(1):2490. PMID: 33941775
Gang Yuan*, Natasha M. Flores*, Simone Hausmann, Shane M. Lofgren, Vladlena Kharchenko, Maria Angulo-Ibanez, Deepawita Sengupta, Xiaoyin Lu, Iwona Czaban, Dulat Azhibek, Silvestre Vicent, Wolfgang Fischle, Mariusz Jaremko, Bingliang Fang, Ignacio I. Wistuba, Katrin F. Chua, Jack A. Roth, John D. Minna, Ning-Yi Shao#, Łukasz Jaremko#, Pawel K. Mazur# and Or Gozani#. Elevated NSD3 Histone Methylation Activity Drives Squamous Cell Lung Cancer. Nature, 2021, Feb; 590(7846):504-508. PMID: 33536620
Kamakoti P. Bhat*, H. Ümit Kaniskan*, Jian Jin# and Or Gozani#. Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease. Nature Reviews Drug Discovery, 2021
Wanqiu Li*, Wei Tian*, Gang Yuan*, Pujuan Deng*, Deepanwita Sengupta, Yinghua Cao, Jiahao Ren, Yuqiao Zhou, Yan Qin, Yulin Jia, Or Gozani#, Dinshaw J. Patel# and Zhanxin Wang#. Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases. Nature, 2021, Feb; 590(7846): 498-503. PMID: 33361816
2020
Li TM, Ren J, Husmann D, Coan JP, Gozani O#, Chua KF#. Multivalent tumor suppressor adenomatous polyposis coli promotes Axin biomolecular condensate formation and efficient b-catenin degradation. Scientific Reports. 2020 Oct 15;10(1):17425. PMID: 33060621
Ren W, Fan H, Grimm SA, Guo Y, Kim JJ, Yin J, Li L, Petell CJ, Tan XF, Zhang ZM, Coan JP, Gao L, Cai L, Detrick B, Çetin B, Cui Q, Strahl BD, Gozani O, Wang Y, Miller KM, O'Leary SE, Wade PA, Patel DJ, Wang GG, Song J. Direct readout of heterchromatic H3K9me3 regulates DNMT1-mediated maintenance DNA methylation. Proc Natl Acad SciU S A. 2020 Aug 4;117(31):18439-18447. PMID: 32675241
Zoabi M, Zhang L, Li TM, Elias JE, Carlson SM and Or Gozani. Methyltransferase-like 21C (METTL21C) methylates alanine tRNA synthetase at Lys-943 in muscle tissue. J Biol Chem. 2020 Aug 14;295(33):11822-11832. PMID: 32611769
Wang Z*, Hausmann S*, Lyu R, Li TM, Lofgren SM, Flores NM, Fuentes ME, Caporicci M, Yang Z, Meiners MJ, Cheek MA, Howard SA, Zhang L, Elias JE, Kim MP, Maitra A, Wang H, Bassik MC, Keogh MC, Sage J, Gozani O#, Mazur PK#. SETD5-Coordinated Chromatin Reprogamming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy. Cancer Cell. 2020 Jun 8;37(6):834-849.e13. PMID: 32442403
Shaobo Dai, John R. Horton, Alex W. Wilkinson, Or Gozani, Xing Zhang and Xiaodong Cheng (2020) An engineered variant of SETD3 methyltransferase alters target specificity from histidine to lysine methylation. J Biol Chem. 2020, Feb 28;295(9):2582-2589. PMID: 31911441
2019
Bohdan B. Khomtchouk*, Diem-Trang Tran*, Kasra A. Vand, Matthew Might, Or Gozani and Themistocles L. Assimes (2019) Cardioinformatics: the nexus of bioinformatics and precision cardiology. Briefings in Bioinformatics. 2019, PMID: 31802103
Dylan Husmann and Or Gozani. Histone lysine methyltransferases in biology and disease (2019). Nature Structure and Molecular Biology. 2019 Oct; 26(10):880-889; PMID 31582846
Jonathan Diep*, Yaw Shin Ooi*, Alex W. Wilkinson*, Christine E. Peters, Eileen Foy, Jeffrey R. Johnson, James Zengel, Siyuan Ding, Kuo-Feng Weng, Orly Laufman, Gwendolyn Jang, Tracy Young, Erik Verschüren, Kristi Kobluk, Peter Sarnow, Harry B. Greenberg, Ruth Hüttenhain, Claude M. Nagamine, Raul Andino#, Nevan J. Krogan#, Or Gozani#, Jan E. Carette# (2019) Enterovirus Pathogenesis Requires the Host Methyltransferase SETD3. Nature Microbiology, Sept 16; 10.10138/s441564-019-0551-1 PMID: 31527793
Dai S, Horton JR, Woodcock CB, Wilkinson AW, Zhang X, Gozani O and X Cheng (2019) Structural basis for the target specificity of actin histidine methyltransferase SETD3. Nature Communications. 2019 Aug 6;10(1):3541 PMID: 31388018
Tie-Mei Li*, John P. Coan*, Krzysztof Krajewski, Lichao Zhang, Joshua E. Elias, Brian D. Strahl, Or Gozani# and Katrin F. Chua#. Binding to medium and long chain fatty acyls is a common property of HEAT and ARM repeat modules (2019). Scientific Reports. Oct 2;9(1):14226. PMID 315784817
Bohdan B. Khomtchouk, Kasra A. Vand*, William C. Koehler*, Diem-Trang Tran, Kai Middlebrook, Shyam Sudhakaran, Christopher S. Nelson, Or Gozani and Themistocles L. Assimes (2019) HeartBioPortal: An Internet-of-Omics for Human Cardiovascular Disease Data. Circulation: Genomic and Precision Medicine. 2019 Ap;12(4):e002426. doi: 10.1161/CIRCGEN.118.002426 PMID: 31294639
Shuo Liu*, Simone Hausmann*, Scott Moore Carlson, Mary Esmeralda Fuentes, Joel William Francis, Renjitha Pillai, Shane Michael Lofgren, Laura Hulea, Kristofferson Tandoc, Jiuwei Lu, Ami Li, Nicholas Dang Nguyen, Marcello Caporicci, Michael Paul Kim, Anirban Maitra, Huamin Wang, Ignacio Ivan Wistuba, John Anthony Porco, Jr., Michael Cory Bassik, Joshua Eric Elias, Jikui Song, Ivan Topisirovic, Capucine Van Rechem, Pawel Karol Mazur# and Or Gozani# (2019) METTL13 methylation of eEF1A increases translational output to promote tumorigenesis. Cell 2019 Jan 24;176(3):491-504, PMID: 30612740
2018
Alex W. Wilkinson*, Jonathan Diep*, Shaobo Dai*, Shuo Liu, Yaw Shin Ooi, Dan Song, Tie-Mei Li, John R. Horton, Xing Zhang, Chao Liu, Darshan V. Trivedi, Katherine M. Ruppel, José G. Vilches-Moure, Kerriann M. Casey, Justin Mak, Tina Cowan, Joshua E. Elias, Claude M. Nagamine, James A. Spudich, Xiaodong Cheng#, Jan E. Carette# and Or Gozani# (2018) SETD3 is an Actin Histidine Methyltransferase that Prevents Primary Dystocia. Nature, 10.1038/s41586-018-0821-8. (Advance Online Publication Dec 10, 2018); 2019 Jan;565(7739):372-376; PMID: 30626964
2017
Sankaran SM, Gozani O. (2017) Characterization of H3.3K36M as a tool to study H3K36 methylation in cancer cells. Epigenetics. 2017;12(11):917-922. PMID: 28933651
Kutateladze TG, Gozani O, Bienz M, Ostankovitch M. (2017) Histone modifications for chromatin dynamics and cellular plasticity. J Mol Biology. 2017 Jun 30;429(13):1921-1923. PMID: 28623961
Carlson SM, Soulette CM, Yang Z, Elias JE, Brooks AN, Gozani O. (2017) RBM25 is a global splicing factor promoting inclusion of alternatively spliced exons and is itself regulated by lysine mono-methylation. J Biol Chem. 2017 Jun 27. pii: jbc.M117.784371. PMID: 28655759
Wilkinson AW, Gozani O. (2017) Cancer epigenetics: Reading the future of leukaemia. Nature, 2017 Mar 1. doi: 10.1038/nature21894. PMID: 28241142
2016
Carlson SM, Gozani O. (2016) Nonhistone Lysine Methylation in the Regulation of Cancer Pathways. Cold Spring Harb Perspect Med. 2016 Nov 1;6(11). pii: a026435. doi: 10.1101/cshperspect.a026435 PMID: 27580749
Huang WH, Guenthner CJ, Xu J, Nguyen T, Schwarz LA, Wilkinson AW, Gozani O, Chang HY, Shamloo M, Luo L. (2016) Molecular and Neural Functions of Rai1, the Causal Gene for Smith-Magenis Syndrome. Neuron. 2016 Oct 19;92(2):392-406. doi: 10.1016/j.neuron.2016.09.019.PMID: 27693255
Mazur PK, Gozani O, Sage J, Reynoird N. Novel insights into the oncogenic function of the SMYD3 lysine methyltransferase. Transl Cancer Res. 2016 Jun;5(3):330-333. PMID: 30713830
Munehira Y, Yang Z, Gozani O. (2016) Systematic Analysis of Known and Candidate Lysine Demethylases in the Regulation of Myoblast Differentiation. J Mol Biology. 2016 Oct 11. pii: S0022-2836(16)30419-3. doi: 10.1016/j.jmb.2016.10.004. PMID: 27732873
Zhu L, Li Q, Wong SH, Huang M, Klein BJ, Shen J, Ikenouye L, Onishi M, Schneidawind D, Buechele C, Hansen L, Duque-Afonso J, Zhu F, Mas Martin G, Gozani O, Majeti R, Kutateladze TG, Cleary ML.(2016) ASH1L links histone H3 lysine 36 di-methylation to MLL leukemia. Cancer Discovery. 2016 May 6. pii: CD-16-0058. PMID: 27154821
Nicolas Reynoird*, Pawel K. Mazur*, Timo Stellfeld, Natasha M. Flores, Shane M. Lofgren, Scott M. Carlson, Elisabeth Brambilla, Pierre Hainaut, Ewa B. Kaznowska, Cheryl H. Arrowsmith, Purvesh Khatri, Carlo Stresemann, Or Gozani#, and Julien Sage# (2016) Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer. Genes and Development. 2016 Apr 1;30(7):772-85. PMID: 26988419
Li S, Yang Z, Du X, Liu R, Wilkinson AW, Gozani O, Jacobsen SE, Patel DJ, Du J. (2016) Structural Basis for the Unique Multivalent Readout of Unmodified H3 Tail by Arabidopsis ORC1b BAH-PHD Cassette. Structure. 2016 Mar 1;24(3):486-94. PMID: 26876097
Sankaran SM, Wilkinson AW, Gozani O. (2016) A PWWP domain of histone-lysine N-methyltransferase NSD2 binds to dimethylated Lys36 of histone H3 and regulates NSD2 function at chromatin. J Biol Chem. 2016 Apr 15;291(16):8465-74. doi: 10.1074/jbc.M116.720748. PMID: 26912663
van Nuland R, Gozani O. (2015) H4K20 methylation: expanding the signaling potential of the proteome one methyl moiety at a time. Molecular Cell Proteomics. 2016 Mar;15(3):755-64. PMID: 26598646
2015
Shoudeng Chen#, Ze Yang#, Alex W. Wilkinson#, Aniruddha J. Deshpande, Simone Sidoli, Krzysztof Krajewski, Brian D. Strahl, Benjamin A. Garcia, Scott A. Armstrong, Dinshaw J. Patel# and Or Gozani# (2015) The PZP domain of AF10 senses unmodified H3K27 to regulate DOT1L-mediated methylation of H3K79. Molecular Cell. 2015 Oct 15;60(2):319-27. PMID: 26439302
Zhang W, Sankaran S, Gozani O, Song J. (2015) A Meier-Gorlin syndrome mutation impairs the ORC1-nucleosome association. ACS Chem Biol. 2015 May 15;10(5):1176-80. PMID: 25689043
Carlson SM, Moore KE, Sankaran SM, Reynoird N, Elias JE, Gozani O. (2015) A Proteomic Strategy Identifies Lysine Methylation of Splicing Factor snRNP70 by the SETMAR Enzyme. J Biol Chem. 2015 May 8;290(19):12040-7. PMID: 25795785
2014
Zhongjun Cheng, Peggie Cheung, Alex J. Kuo, Erik T. Yukl, Carrie M. Wilmot, Or Gozani# and Dinshaw J. Patel#. (2014) A Molecular Threading Mechanism Underlies Jumonji Lysine Demethylase KDM2A Regulation of Methylated H3K36. Genes and Development. 2014, 15;28(10): 1758-71. PMID: 25128496
Reynoird N, Gozani O. (2014) Nuclear PI5P, Uhrf1, and the Road Not Taken. Molecular Cell. 2014 Jun 19;54(6):901-3. PMID: 24950375
Pawel K. Mazur*, Nicolas Reynoird*, Purvesh Khatri, Pascal W.T.C. Jansen, Alex Wilkinson, Shichong Liu, Olena Barbash, Glenn S. Van Aller, Michael Huddleston, Dashyant Dhanak, Peter J. Tummino, Ryan G. Kruger, Benjamin Garcia, Atul J. Butte, Michiel Vermeulen, Julien Sage#, and Or Gozani# (2014). SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer. Nature. 2014 Jun 12;510(7504):283-7. PMID 24847881
Carlson SM, Gozani O. Emerging Technologies to Map the Protein Methylome. J Mol Biology. 2014 May 5. S0022-2836(14). PMID: 24805349
Moore KE and Gozani O. An unexpected journey: Lysine methylation across the proteome. 2014. Biochim Biophys Acta. 2014 Dec;1839(12):1395-403. PMID: 24561874
Wilkinson A and Gozani O. Histone-binding domains: Strategies for discovery and characterization. 2014. Biochim Biophys Acta 2014, Aug;1839(8):669-75. PMID: 24525102
Martin GM, King DA, Green EM, Garcia-Nieto PE, Alexander R., Collins SR, Krogan NJ, Gozani O, and Morrison AJ. Set5 and Set1 cooperate to repress gene expression at telomeres and retrotransposons. 2014. Epigenetics. Apr;9(4):513-22. PMID: 24442241
Carlson SM, Moore KE, Green EM, Martin GM, and Gozani O. Proteome-wide enrichment of proteins modified by lysine methylation. 2014. Nature Protocols. Jan;9(1):37-50. PMID: 24309976
Or Gozani and Yang Shi, Chapter 5: Histone Methylation in Chromatin Signaling, Fundamentals of Chromatin, edited by Jerry Workman and Susan Abmayr, Springer Press, New York (2014)
2013
Bua DJ, Martin GM, Binda O, and Gozani O. Nuclear phosphatidylinositol-5-phospate regulates ING2 stability at discrete chromatin targets in response to DNA damage. Scientific Reports. 2013; 3:2137. PMID: 23823870
Moore KE, Carlson SM, Camp ND, Cheung P, James RG, Chua KF, Wolf-Yadlin A, Gozani O. A General Molecular Affinity Strategy for Global Detection and Proteomic Analysis of Lysine Methylation. Molecular Cell. 2013 May 9;50(3):444-56. PMID: 23583077
Paul S, Kuo A, Schalch T, Vogel H, Joshua-Tor L, McCombie WR, Gozani O, Hammell M, Mills AA. Chd5 requires PHD-mediated histone 3 binding for tumor suppression. Cell Reports. 2013 Jan 31;3(1):92-102. PMID: 23318260
2012
Ballaré C, Lange M, Lapinaite A, Martin GM, Morey L, Pascual G, Liefke R, Simon B, Shi Y, Gozani O, Carlomagno T, Benitah SA, Di Croce L. Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity. Nature Structure and Molecular Biology. 2012 Dec;19(12):1257-65. PMID: 23104054
Price JV, Tangsombatvisit S, Xu G, Yu J, Levy D, Baechler EC, Gozani O, Varma M, Utz PJ, Liu CL. On silico peptide microarrays for high-resolution mapping of antibody epitopes and diverse protein-protein interactions. Nature Medicine. 2012 Sep;18(9):1434-40. PMID: 22902875
Green EM, Gozani O. Everybody’s welcome: The big tent approach to epigenetic drug discovery. Drug Discov Today There Strateg. 2012 Fall;9(2-3):e75-e81. PMID: 23505394
Calnan DR, Webb AE, White JL, Stowe TR, Goswami T, Shi X, Espejo A, Bedford MT, Gozani O, Gygi SP, Brunet A. Methylation by Set9 modulates FoxO3 stability and transcriptional activity. Aging.(Albany NY). 2012 Jul;4(7):462-79. PMID: 22820736
Barber MF*, Michishita-Kioi E*, Xi Y, Tasselli L, Kioi M, Moqtaderi Z, Tennen RI, Paredes S, Young NL, Chen K, Struhl K, Garcia BA, Gozani O, Li W, Chua KF. SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature. 2012 Jul 5;487(7405):114-8. PMID: 22722849
Green EM, Morrison AJ, Gozani O. New marks on the block: Set5 methylates H4 lysines 5, 8 and 12. Nucleus. 2012 Jul 1;3(4):335-9. PMID: 22688645
Van Aller GS, Reynoird N, Barbash O, Huddleston M, Liu S, Zmoos AF, McDevitt P, Sinnamon R, Le B, Mas G, Annan R, Sage J, Garcia BA, Tummino PJ, Gozani O, Kruger RG. Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation. Epigenetics. 2012 Apr;7(4):340-3. PMID: 22419068
Kuo AJ*, Song J*, Cheung P*, Ishibe-Murakami S, Yamazoe S, Chen JK, Patel DJ#, Gozani O#.The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome. Nature. 2012 Mar 7;484(7392):115-9. PMID: 22398447
Green EM, Mas G, Young NL, Garcia BA, Gozani O. Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses. Nature Structure and Molecular Biology. 2012 Feb 19;19(3):361-3. PMID: 22343720
Liu CL, Tangsombatvisit S, Rosenberg JM, Mandelbaum G, Gillespie EC, Gozani OP, Alizadeh AA, Utz PJ. Specific post-translational histone modifications of neutrophil extracellular traps as immunogens and potential targets of lupus autoantibodies. Arthritis Res Ther. 2012 Feb 2;14(1):R25. PMID: 22300536
2011
Kuo AJ, Cheung P, Chen K, Zee BM, Kioi M, Lauring J, Xi Y, Park BH, Shi X, Garcia BA, Li W, Gozani O. NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming. Molecular Cell. 2011 Nov 18;44(4):609-20. PMID: 22099308
Levy D, Liu CL, Yang Z, Newman AM, Alizadeh AA, Utz PJ, Gozani O. A proteomic approach for the identification of novel lysine methyltransferase substrates. Epigenetics Chromatin. 2011 Oct 24;4:19. PMID: 22024134
West LE, Gozani O. Regulation of p53 function by lysine methylation. Epigenomics. 2011 Jun;3(3):361-9. PMID: 21826189
Lee JS, Kim Y, Bhin J, Shin HJ, Nam HJ, Lee SH, Yoon JB, Binda O, Gozani O, Hwang D, Baek SH . Hypoxia-induced methylation of a pontin chromatin remodeling factor. Proc Natl Acad Sci USA. 2011 Aug 16;108(33):13510-5. PMID: 21825155
Green EM, Gozani O. CUL4B: trash talking at chromatin. Molecular Cell. 2011 Aug 5;43(3):321-3. PMID: 21816341
Chang Y, Levy D, Horton JR, Peng J, Zhang X, Gozani O, Cheng X. Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling. Nucleic Acids Res. 2011 Aug;39(15):6380-9. PMID: 21515635
Dan Levy, Alex J. Kuo, Yanqi Chang, Uwe Schaefer, Christopher Kitson, Peggie Cheung, Alexsandra Espejo, Barry M. Zee, Chih Long Liu, Stephanie Tangsombatvisit, Ruth I. Tennen, Andrew Y. Kuo, Song Tanjing, Regina Cheung, Katrin F. Chua, Paul J. Utz, Xiaobing Shi, Rab K. Prinjha, Kevin Lee, Benjamin A. Garcia, Mark T. Bedford, Alexander Tarakhovsky, Xiaodong Cheng and Or Gozani (2011). Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling. Nature Immunology. 12(1):29-36. PMID: 21131967
Olivier Binda, Michael Boyce, Jason S. Rush, Krishnan K. Palaniappan, Carolyn R. Bertozzi, and Or Gozani (2011). A Chemical Method for Labeling Lysine Methyltransferase Substrates. Chembiochem. Jan 24;12(2):330-4. PMID: 21243721
2010
Tsai WW, Wang Z, Yiu TT, Akdemir KC, Xia W, Winter S, Tsai CY, Shi X, Schwarzer D, Plunkett W, Aronow B, Gozani O, Fischle W, Hung MC, Patel DJ, Barton MC. TRIM24 links a non-canonical histone signature to breast cancer. Nature. 2010 Dec 16;468(7326):927-32. PMID: 21164480
Binda O, LeRoy G, Bua DJ, Garcia BA, Gozani O, Richard S. Trimethylation of histone H3 lysine 4 impairs methylation of histone H3 lysine 9: regulation of lysine methyltransferases by physical interaction with their substrates. 2010. Epigenetics. Nov-Dec;5(8):767-75. PMID: 21124070
Lisandra E. West, Siddhartha Roy, Karin Lachmi-Weiner, Ryo Hayashi, Xiaobing Shi, Ettore Appella, Tatiana G. Kutateladze#, and Or Gozani# (2010). The MBT repeats of L3MBTL1 link set8 mediated p53 methylation at lysine 382 to target gene repression. J Biol Chem. 2010 Nov 26;285(48):37725-32. PMID: 20870725
Louis A. Saddic, Lisandra E. West, Aaron Aslanian, John R. Yates, Seth M. Rubin, Or Gozani, and Julien Sage (2010). Methylation of the retinoblastoma tumor suppressor by SMYD2. J Biol Chem. 2010 Nov 26;285(48):37733-40. PMID: 20870719
Dan Levy and Or Gozani (2010). Decoding chromatin goes high tech. Cell. Sept 17;142(6):844-6. PMID: 20850007
Greer EL, Maures TJ, Hauswirth AG, Green EM, Leeman DS, Maro GS, Han S, Banko MR, Gozani O, Brunet A. (2010) Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans. Nature. Jul 15;466(7304):383-7. PMID: 20555324
Kleine-Kohlbrecher D, Christensen J, Vandamme J, Abarrategui I, Bak M, Tommerup N, Shi X, Gozani O, Rappsilber J, Salcini AE, Helin K (2010). A Functional Link between the Histone Demethylase PHF8 and the Transcription Factor ZNF711 in X-Linked Mental Retardation. Molecular Cell. April 23;38(2):165-78. PMID: 20346720
Chang PY, Hom RA, Musselman CA, Zhu L, Kuo A, Gozani O, Kutateladze TG, Cleary ML (2010). Binding of the MLL PHD3 finger to histone H3K4me3 is required for MLL-dependent gene transcription. J Mol Biology. July 9,400(2):137-44. PMID: 20452361
Hom RA, Chang PY, Roy S, Musselman CA, Glass KC, Selezneva AI, Gozani O, Ismagilov RF, Cleary ML, Kutateladze TG (2010). Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain. J Mol Biology. July 9;400(2):145-54. PMID: 20460131
Lee JS, Kim Y, Kim IS, Kim B, Choi HJ, Lee JM, Shin HJ, Kim JH, Kim JY, Seo SB, Lee H, Binda O, Gozani O, Semenza GL, Kim M, Kim KI, Hwang D, Baek SH (2010). Negative regulation of hypoxic responses via induced Reptin methylation. Molecular Cell. Jul 9;39(1):71-85. PMID: 20603076
Roy S, Musselman CA, Kachirskaia I, Hayashi R, Glass KC, Nix JC, Gozani O, Appella E, Kutateladze TG (2010). Structural insight into p53 recognition by the 53BP1 tandem Tudor domain. J Mol Biology. May 14;398(4):489-96. PMID: 20307547
2009
Dennis J. Bua, Alex J. Kuo, Peggie Cheung, Chih Long Liu, Valentina Migliori, Alexsandra Espejo, Fabio Casadio, Christian Bassi, Bruno Amati, Mark T. Bedford, Ernesto Guccione, and Or Gozani. (2009) Epigenome Microarray Platform for Proteome-Wide Dissection of Chromatin-Signaling Networks. PLoS ONE 2009, Aug 26;4(8). PMID: 19956676
Michishita E, McCord RA, Boxer LD, Barber MF, Hong T, Gozani O, Chua KF (2009). Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6. Cell Cycle. Aug 8(16):2664-6. PMID: 19625767
Li Y, Trojer P, Xu CF, Cheung P, Kuo A, Drury WJ 3rd, Qiao Q, Neubert TA, Xu RM, Gozani O, Reinberg D (2009). The target of the NSD family of histone lysine methyl transferases depends on the nature of the substrate. J Biol Chem, 2009, Dec 4;284(49):34283-34295. PMID: 19808676
McCord RA, Michishita E, Hong T, Berber E, Boxer LD, Kusumoto R, Guan S, Shi X, Gozani O, Burlingame AL, Bohr VA, and Chua KF (2009).SIRT6 stabilizes DNA-dependent Protein Kinase at chromatin for DNA double-strand break repair. Aging Jan 15;1(1):109-121. PMID: 20157594
Nehmé Saksouk, Nikita Avvakumov ,Karen S. Champagne, Tiffany Hung, Yannick Doyon, Christelle Cayrou, Eric Paquet, Mukta Ullah, Anne-Julie Landry, Valérie Côté, Xiang-Jiao Yang, Or Gozani, Tatiana G. Kutateladze and Jacques Côté. (2009) HBO1 HAT Complexes Target Chromatin throughout Gene Coding Regions via Multiple PHD Finger Interactions with Histone H3 Tail. Molecular Cell, Jan 30; 33(2): 257-265. PMID: 19187766
Tiffany Hung, Olivier Binda, Karen S. Champagne, Alex J. Kuo, Kyle Johnson, Howard Y. Chang, Matthew D. Simon, Tatiana G. Kutateladze and Or Gozani (2009). ING4 mediates crosstalk between histone H3K4 trimethylation and H3 acetylation to attenuate cellular transformation. Molecular Cell, Jan 30; 33(2): 248-256. PMID: 19187765
2008
Pedro V. Peña, Catherine A. Musselman, Alex J. Kuo, William P. Schiemann, Or Gozani, and Tatiana G. Kutateladze (2008). NMR assignments and histone specificity of the ING2 PHD. Magnetic Resonance in Chemistry, Apr. 47(4): 352-358. PMID: 19184981
Koh AS, Kuo AJ, Park SY, Cheung P, Abramson J, Bua D, Carney D, Shoelson SE, Gozani O, Kingston RE, Benoist C, and D. Mathis (2008). Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity. Proc Natl Acad Sci, Oct 14;105(41): 15878-83. PMID: 18840680
Kachirskaia I, Shi X, Yamaguchi H, Tanoue K, Wen H, Wang EW, Appella E, and O. Gozani (2008). Role for 53BP1 tudor domain recognition of p53 dimethylated at lysine 382 in DNA damage signaling. Journal of Biological Chemistry, Dec 12; 283(50):34660-6. PMID: 18840612
Peña PV, Hom RA, Hung T, Lin H, Kuo AJ, Wong RP, Subach OM, Champagne KS, Zhao R, Verkhusha VV, Li G, Gozani O, and TG Kutateladze (2008). Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor. J Mol Biology, Jul 4; 380(2):303-12. PMID: 18533182
Michishita, E., McCord, R.A., Berber E., Kioi, M., Padilla-Nash, H,, Damian, M., Cheung, P., Kusomoto, R., Kawahara, T.L.A., Barrett, J.C., Chang, H.Y., Bohr, V.A., Ried, T., Gozani, O. and K.F. Chua (2008). SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature, Mar 27;452(7186):492-6. PMID: 18337721
2007
Adam G. W. Matthews*, Alex J. Kuo*, Santiago Ramon-Maiques, Sunmi Han, Karen S. Champagne, Dmitri Ivanov, Mercedes Gallardo, Dylan Carney, Peggie Cheung, David N. Ciccone, Kay L. Walter, Paul J. Utz, Yang Shi, Tatiana G. Kutateladze, Wei Yang, Or Gozani# & Marjorie A. Oettinger# (2007). RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature, Dec 13; 450(7172):1106-10. PMID: 18033247
Santiago Ramon-Maiques, Alex J. Kuo, Dylan Carney, Adam G. W. Matthews, Marjorie A. Oettinger, Or Gozani, and Wei Yang (2007). The PHD finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2. PNAS, 104(48):18993-8. PMID: 18025461
Shi, X., Kachirskaia, I., Yamaguchi, H., West, L.E., Wen, H., Wang, E.W., Dutta, S., Appella, E. and Or Gozani (2007). Modulation of p53 function by SET8-mediated methylation at lysine 382. Molecular Cell, Aug 17;27: 636-646. PMID: 17707234
Lan F, Collins RE, De Cegil R, Alpatov R, Horton JR, Shi X, Gozani O, Cheng X, Y. Shi (2007). Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression. Nature. 2007 Aug 9;448(7154):718-22. PMID: 17687328
Huang, W., Zhang, H., Davrazou, F., Kutateladze, T.G., Shi, X., Gozani, O. and G.D. Prestwich (2007). Stabilized Phosphatidylinositol-5-Phosphate Analogues as Ligands for the Nuclear Protein ING2: Chemistry, Biology and Molecular Modeling. JACS May 23;129(20):6498-506. PMID: 17469822
Shi, X., Kachirskaia, I., Walter K.L., Kuo, J.H., Lake A., Davrazou, F., Chan, S.M., Martin, D.G., Fingerman, I.M., Briggs, S.D., Howe, L., Utz, P.J., Kutateladze, T.G., Lugovskoy, A.A., Bedford, M.T., and O. Gozani(2007). Proteome-wide analysis in S. cerevisae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36. JBC, Jan 26;282, 2450-2455. PMID: 17142463
2006
David G. E. Martin, Kristin Baetz, Xiaobing Shi, Kay L. Walter, Vicki E. MacDonald, Martin J. Wlodarski, Or Gozani, Philip Hieter, and LeAnn Howe (2006). The Yng1p Plant Homeodomain Finger Is a Methyl-Histone Binding Module That Recognizes Lysine 4-Methylated Histone H3. MCB, Nov;26: 7871-7879. PMID: 16923967
Xiaobing Shi, Tao Hong, Kay L. Walter, Mark Ewalt, Eriko Michishita, Tiffany Hung, Dylan Carney, Pedro Peña, Fei Lan, Mohan R. Kaadige, Nicolas Lacoste, Christelle Cayrou Foteini Davrazou, Anjanabha Saha, Bradley R. Cairns, Donald E. Ayer, Tatiana G. Kutateladze, Yang Shi, Jacques Côté, Katrin F. Chua, and Or Gozani (2006). ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature, July 6;442, 96-99. PMID: 16728974
Pedro V. Peña, Foteini Davrazou, Xiaobing Shi, Kay L. Walter, Vladislav V. Verkhusha, Or Gozani, Rui Zhao and Tatiana G. Kutateladze (2006). Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2. Nature, Jul 6;442, 100-103. PMID: 16728977
Caroline Pendaries, Hélène Tronchère, Laurence Arbibe, Joelle Mounier, Or Gozani, Lewis Cantley, Michael J Fry, Frédérique Gaits-Iacovoni, Philippe J Sansonetti and Bernard Payrastre (2006). PtdIns(5)P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection. The EMBO Journal, March 25: 1024-1034. PMID: 16482216
2005
Xiaobing Shi and Or Gozani (2005). The Fellowships of the INGs. Journal of Cellular Biochemistry, Dec 15;96(6): 1127-1136. PMID: 16167330
Sheryl K. Elkin, Dmitri Ivanov, Mark Ewalt, Colin G. Ferguson, Sven G. Hyberts, Zhen-Yu J. Sun, Glenn D. Prestwich, Junying Yuan, Gerhard Wagner, Marjorie A. Oettinger, Or Gozani (2005). A PHD finger motif in the C-terminus of RAG2 modulates recombination activity. JBC, Aug. 5;280(31): 28701-10. PMID: 15964836